September 1, 20023 | No 346
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Food for thought:
Challenges pave the way for growth and success. Conquer them with resilience and determination to unlock your true potential. Let challenges ignite your motivation, propelling you towards greatness. Remember, every challenge is an opportunity in disguise.
What is your view on supplements. Should I take them?
A: If your diet lacks essential nutrients, supplements, vitamins, and minerals can play a vital role in supporting your overall well-being. They act as a convenient and effective way to bridge the nutritional gaps in your daily routine.
By incorporating these supplements into your diet, you can ensure that your body receives the necessary nutrients it needs to thrive. This is all up to you and your needs depending on the food you eat. I recommend adding a multivitamin and mineral supplement as a minimum.
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THINGS WE FIND INTERESTING
We enjoy sharing interesting findings with you and hope they pique your interest too. While we may not always endorse or agree with everything we share, we strive to provide information that can aid you in your pursuit of mental and physical wellness.
Exercise gets harder the less you do, here is why.
New research suggests that a vital protein in the body may be deactivated if one reduces their exercise routine, leading to more inactivity and making it harder to exercise.
Scientists from the University of Leeds have made a new finding that deactivating the Piezo1 protein, which acts as a blood flow sensor, can lead to a decrease in the number of capillaries that transport blood to the muscles.
The team discovered that restricted blood flow makes physical activity more challenging and can result in decreased exercise capacity. These findings shed light on the biological reasons behind the difficulty of exercising when one is not active enough.
The paper titled “Endothelial Piezo1 Sustains Muscle Capillary Density and Contributes to Physical Activity” has been published in The Journal of Clinical Investigation.
The experiments were carried out in mice, but the Piezo1 protein is found in humans, suggesting the same results could occur.
Fiona Bartoli, the lead author and a Postdoctoral Researcher at the University of Leeds’ School of Medicine, explains that exercise offers protection against a range of diseases, including cardiovascular disease, diabetes, depression, and cancer. However, many individuals do not exercise enough due to reasons such as injury or excessive computer usage, which increases their risk of these diseases. Furthermore, individuals who exercise less become less fit, which often leads to a negative cycle.
While there are numerous known responses to exercise, the initial molecular trigger for the benefits of exercise remains a mystery. Our study emphasizes the critical connection between physical activity and physical performance, which is established at the molecular level by Piezo1. Maintaining the activity of our Piezo1s through exercise may play a vital role in our overall physical performance and health.
In the experiment, two sets of mice were compared by scientists – a control group and another group whose Piezo1 levels were disrupted for 10 weeks. The mice were observed while walking, climbing and running on a wheel, and it was observed that the Piezo1 mice had significantly lower levels of physical activity. This indicates that Piezo1 plays an important role in maintaining normal physical activity.
The researchers conducted a study to investigate if Piezo1 mice showed less interest in exercise. However, they did not find any differences in the amount or duration of activity between the two groups. Instead, they observed that the Piezo1 mice had fewer running wheel revolutions per exercise session and a slower running speed, indicating a reduced ability to exercise rather than a lack of desire.
Professor David Beech, the lead author in the School of Medicine at the University of Leeds, has revealed new insights into the connection between Piezo1’s role in blood vessels and physical activity. While its involvement in blood vessel development was already established, its contribution to vessel maintenance in adults was less understood.
This new discovery presents a chance to explore alternative methods of treating muscle loss. By activating Piezo1, there may be a possibility of preserving one’s ability to exercise. The study was financially supported by the British Heart Foundation.
- Fiona Bartoli, Marjolaine Debant, Eulashini Chuntharpursat-Bon, Elizabeth L. Evans, Katie E. Musialowski, Gregory Parsonage, Lara C. Morley, T. Simon Futers, Piruthivi Sukumar, T. Scott Bowen, Mark T. Kearney, Laeticia Lichtenstein, Lee D. Roberts, David J. Beech. Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity. Journal of Clinical Investigation, 2022; 132 (5) DOI: 10.1172/JCI141775
The article originally appeared in:
University of Leeds. “Why exercise gets harder the less you do.” ScienceDaily. ScienceDaily, 28 February 2022. www.sciencedaily.com/releases/2022/02/220228191000.htm.
What is the Piezo1 protein?
The PIEZO1 protein, also known as “Piezo-type mechanosensitive ion channel component 1,” is a transmembrane protein that plays a crucial role in mechanotransduction, which is the process by which mechanical stimuli are converted into cellular responses. PIEZO1 is a mechanically activated ion channel that allows the passage of ions across the cell membrane in response to mechanical forces such as pressure, stretch, or tension.
This protein is particularly important in various physiological processes where cells need to sense and respond to mechanical cues. PIEZO1 is found in a wide range of cell types, including those in blood vessels, the lungs, the skin, and various other tissues. Some of its notable functions include:
- Red Blood Cell Volume Regulation: In red blood cells, PIEZO1 helps regulate cell volume by allowing the influx of ions in response to changes in blood pressure. This is important for maintaining cell shape and function.
- Vascular System Regulation: In endothelial cells lining blood vessels, PIEZO1 helps sense blood flow and pressure changes, which can influence vascular tone and blood pressure regulation.
- Lung Function: In lung cells, PIEZO1 plays a role in sensing stretch and mechanical changes during breathing. It is involved in various lung-related processes such as lung development and response to injury.
- Pain Sensation: PIEZO1 is also found in sensory neurons, where it contributes to the sensation of touch and other mechanical stimuli. It is implicated in sensing pain associated with mechanical force.
- Bladder Function: In bladder cells, PIEZO1 is involved in sensing bladder stretch and pressure changes, which are important for bladder function and control.
- Development: PIEZO1 is thought to be involved in various developmental processes, including the development of the nervous system and cardiovascular system.
The discovery of PIEZO1 has greatly expanded our understanding of how cells sense and respond to mechanical forces. Mutations in the PIEZO1 gene have been associated with various medical conditions, known as PIEZO1-related diseases. These diseases can affect blood cell disorders, vascular abnormalities, and other conditions related to mechanosensation.
Research into PIEZO1 and its functions is ongoing, and its potential applications range from understanding fundamental cellular processes to developing new therapeutic strategies for conditions related to mechanotransduction dysfunction.
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Here is a 10-minutes abs workout that will get your blood flowing and boost your energy.
This Week’s Recipe
MEDITERRANEAN CHICKEN ZUCCHINI BAKE
This delicious Mediterranean chicken breast and zucchini bake is a great way to get your family to eat their vegetables! With a mix of flavors from tomato, zucchini, herbs, and cheese, this chicken casserole is sure to please even the pickiest of eaters. It’s also a great way to use up any leftover chicken and vegetables you may have on hand. This chicken breast bake recipe is simple to make and great for weeknight dinners. Low-carb, keto-friendly, and gluten-free. Give it a try, and enjoy!
HOW TO MAKE CHICKEN ZUCCHINI CASSEROLE
Start by seasoning the chicken breastwith garlic powder, oregano, salt, and pepper, with a drizzle of olive oil. Top with onion, zucchini, and tomato. Finish of with shredded cheeses. Bake in the oven for 20 to 25 minutes, depending on the size of your chicken breasts.
INGREDIENTS LIST FOR THE CHICKEN ZUCCHINI BAKE
- 2 boneless skinless chicken breasts, sliced horizontally to make 4 cutlets
- 3 tablespoons olive oil
- 2 tablespoons garlic powder
- 1 tablespoon chopped fresh oregano or 1 teaspoon dried oregano
- 1 zucchini, thinly sliced
- 2 tomatoes, chopped
- 1/2 onion, chopped
- 1/2 cup shredded mozzarella
- 1/2 cup grated Parmesan cheese
- 1 tablespoon fresh parsley, for garnish
2. Transfer the chicken breast to a baking dish and top with onion, sliced zucchini, and tomato.
3. Top the chicken breast and vegetables with shredded Parmesan and Mozzarella cheese.
4. Transfer the baking dish to the oven and bake uncovered for about 20 minutes or until the chicken is done. Broil for the last 2-3 minutes if you like.
5. Remove from the oven and allow the chicken casserole to rest for 5 to 10 minutes before serving. Serve the Mediterranean chicken zucchini bake over cauliflower rice, rice, or couscous. Enjoy! ❤️